DECISION-MAKING WITH Treatment Response Assessment Maps (tramS)

Elements TRAMs* is a novel MRI-based methodology for the high resolution depiction of contrast clearance and accumulation, allowing for the differentiation of brain regions with high and low vascular activity

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TRAMs Clinical Use

Clinical Use

High resolution Treatment Response Assessment Maps (TRAMs) derived from conventional 3D contrast-enhanced MRI data provide additional insights into tumor characteristics and thereby support clinicians during treatment response evaluations. Elements TRAMs serve clinical specialties including radiation oncology, neurosurgery, neuro-oncology and neuroradiology.

  • High resolution differentiation between contrast clearance and accumulation
  • Allows for the distinction of brain regions with high and low vascular activity
  • Supports ongoing assessment and clinical decision making before, during and after most treatments for multiple clinical specialties
TRAMs Methodology


Treatment Response Assessment Maps (TRAMs), a novel MRI-based methodology for distinct differentiation of contrast clearance and accumulation, allows for the depiction of brain regions with high (blue) and low (red) vascular activity. The TRAMs methodology was developed at Sheba Medical Center, Tel Aviv, with technology provided by Brainlab.

  • Two acquisitions of standard 3D T1-weighted MRI—one 5 minutes and another 60-105 minutes after injection of a standard dose of contrast agent
  • First series is intelligently subtracted from the second, resulting in the TRAMs
  • TRAMs are high resolution, volumetric maps distinguishing regions of contrast clearance (blue) from contrast accumulation (red) more than one hour post contrast injection



*CE released, FDA clearance pending.