Elements Solutions for Post Treatment AssessmentMore insights with Elements Contrast Clearance Analysis

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Elements Contrast Clearance Analysis is an MRI-based methodology for the differentiation of contrast clearance and accumulation regions in brain tumor datasets. The high-resolution analysis results provide additional insights to support ongoing assessment and decision-making.

Gain insights into tumor characteristics

Differentiate contrast clearance and accumulation areas with high sensitivity and specificity, enabling precise¹ identification of tumor recurrence versus radio necrosis after radiosurgery.

Make optimal treatment decisions

Access additional information to support ongoing assessment of tissue characteristics during follow-ups and confident decision-making throughout the patient journey.

Support disease management workflows

Track patient progression using longitudinal data to detect therapy failure earlier and determine when new interventions are needed.

Turn insights into action

Discover how advanced post-treatment assessment tools can help you make confident decisions for optimal patient care

Developed for diverse clinical specialties

Elements Contrast Clearance Analysis, developed at Sheba Medical Center in Tel Aviv, serves multiple disciplines, including radiosurgery, radiation oncology, neurosurgery, neuro-oncology and neuroradiology.

Clinical insights

High-resolution analysis results, derived from conventional 3D contrast-enhanced MRI data, provide deeper insights into tumor characteristics. This enables differentiation between radiation effects and tumor regrowth, supporting confident decision-making for both initial and follow-up treatments.

Screenshot: Elements Contrast Clearance Analysis

Advanced methodology

Elements Contrast Clearance Analysis requires two standard 3D T1-weighted MRI scans—acquired 5 minutes and 60-105 minutes after contrast agent injection. Intelligent subtraction of the first scan from the second generates volumetric maps that distinguish regions of contrast clearance (blue) from contrast accumulation (red), offering additional insights.

Screenshot: Methodology for Contrast Clearance Analysis from Dual MRI Series

Revolutionize your treatment decisions

Experience how Elements Contrast Clearance Analysis can support confident, data-driven treatment decisions that elevate patient care

Related Information

Ready to add valuable information to your post-treatment assessment?

Bodensohn, R.; Forbrig, R.; Quach, S.; Reis, J.; Boulesteix, A-L; Mansmann, U. et al. (2022): MRI-based contrast clearance analysis shows high differentiation accuracy between radiation-induced reactions and progressive disease after cranial radiotherapy. In ESMO open 7 (2), p. 100424. DOI: 10.1016/j.esmoop.2022.100424
Source: Novalis Circle 2023 - The use of Contrast Clearance Analysis Software to differentiate Brain Tumors from Radionecrosis: A Revolution?