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Elements Contrast Clearance Analysis

Assess Your Treatments
with More Insights

Elements Contrast Clearance Analysis

Assess Your Treatments with More Insights

Make the optimum treatment decision based on imaging analysis

Elements Contrast Clearance Analysis is an MRI-based methodology for the differentiation of contrast clearance and accumulation regions in brain tumor datasets. The high-resolution analysis results provide additional insights to support you during ongoing assessment and decision-making.

Demo Contrast Clearance Analysis

Clinical use & methodology

Developed at Sheba Medical Center in Tel Aviv, Contrast Clearance Analysis serves multiple clinical specialties including radiosurgery, radiation oncology, neurosurgery, neuro-oncology and neuroradiology.

Three black and white MRI images of a brain taken at three different intervals on top of three corresponding Contrast Clearance Analysis images that show the post brain tumor removal progression of a patient's brain.

Clinical use

High-resolution Contrast Clearance Analysis results derived from conventional 3D contrast-enhanced MRI data provide additional insights into tumor characteristics. These results enable the ongoing assessment of radiation effects versus tumor re-growth to support you in making the most appropriate decisions for initial and follow-up treatments.


The method requires the acquisition of two standard 3D T1-weighted MRIs—one 5 minutes and another 60-105 minutes after injection of a standard dose of contrast agent. The first series is intelligently subtracted from the second for Contrast Clearance Analysis. The analysis results are high-resolution, volumetric maps distinguishing regions of contrast clearance (blue) from contrast accumulation (red).

Side-by-side MRI images of a brain, the left in black and white and the right in color showing the differences in contrast agent clearance by the tissue in the brain.

Learn more about Contrast Clearance Analysis

Clinical paper

Peker et al. 2021

Read more about the use of treatment response assessment maps in discriminating between radiation effect and persistent tumoral lesion in metastatic brain tumors treated with gamma knife radiosurgery.

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Clinical literature library

Advancing medical technology through scientific evidence

Brainlab Clinical Affairs conducts advanced research and gathers scientific evidence to help create safe, efficient, cost-effective medical technology.

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Contrast Clearance Analysis for Differentiating Tumor From Treatment Effects

Dheerendra Prasad, MD of Roswell Park Comprehensive Cancer Center, covers topics including the review of the role of Contrast Clearance Analysis in a high-volume brain radiosurgery practice, discusses modern challenges in the multimodality management of brain metastases and the integration of Elements in the Gamma Knife workflow and more.

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Additional information

Contrast Clearance Analysis Flyer


Contrast Clearance Analysis Technical Background