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Brain Tumor ResectionResection guided 
function protected

Tumor resection demands more than precision. It demands that precision hold as anatomy shifts and conditions evolve. Brainlab connects the brain tumor resection workflow from preoperative planning through intraoperative guidance, supporting informed decisions with the patient at the center.

Resect with confidence
preserve with purpose 

Every resection carries a dual commitment—to remove as much of the tumor as possible, and to protect everything that makes the patient who they are. Our integrated workflow supports both, at every stage of the procedure.

Plan with precision
connect every step 

Successful tumor resection starts with precise preoperative planning. Our solutions bring together anatomical and functional information, navigation, intraoperative imaging and neuromonitoring so each technology can contribute at the right moment. Together, they carry relevant information from the first plan through the procedure, creating a coherent workflow in which every step matters. 

Track progress
guide decisions 

As tumor resection progresses, the anatomy and information in view continue to evolve. Our solutions provide intraoperative guidance and updates to help review anatomy, assess resection progress and guide your next decision.

Make every step count

Learn how an integrated cranial workflow can bring planning, navigation, imaging and functional information together for tumor resection. Speak with our team about the needs of your practice. 

From plan to reality—
the complete tumor resection workflow

A successful resection begins long before the first incision. It begins with understanding—of the tumor, of the anatomy surrounding it and of the patient whose function depends on every decision made. Our workflow connects each phase of that journey, from the clarity that's built in preoperative planning to the real-time intelligence that guides you through resection.

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Understand patient anatomy before you begin

The decisions you make before entering the O.R. shape everything that follows. Brainlab preoperative planning workflow brings together structural and functional imaging to support an informed surgical strategy before the first incision.

Nexstim nTMSBuild surgical strategy on functional insight  

Anatomy alone does not tell the full story. And especially for tumor patients, functional reorganization through neuroplasticity means critical areas may have shifted from where you’d expect them. Nexstim nTMS lets you map motor and language function non-invasively before surgery, making individual functional anatomy visible and actionable. Combined with nTMS-based fiber tracking, functional mapping supports patient-specific surgical decisions and higher resection rates.2

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Cranial Planning with ElementsTurn complexity into clarity 

Every tumor resection case carries its own complexity—intricate anatomical relationships, including critical pathways and eloquent structures, that must be understood before they can be safely navigated. By creating a digital twin of the patient, Elements for Cranial Planning brings together multimodal imaging data in a single, intuitive environment. The plan transfers seamlessly to navigation, so your preoperative insight becomes your intraoperative guide.

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Mixed Reality ViewerSee the case in a new dimension

Two-dimensional imaging can only tell part of the story. The Mixed Reality Viewer3 transforms your planning data into hyper-realistic 3D anatomy—allowing you to interact with the patient's tumor, pathways and surrounding structures before you ever enter the O.R. Explore the safest surgical corridor, assess tumor extent and align your entire care team around a shared spatial understanding of the case.

Brainlab's Mixed Reality Viewer in action, utilized by two individuals in an office setting

Accurate from the start,
adaptable throughout 

In tumor resection, navigational accuracy from the first moment is critical—the difference between a confident approach to the tumor margin and one that leaves room for doubt. Brainlab offers registration methods for different O.R. setups, from automatic registration with Loop-X3 and other intraoperative imaging systems to surface matching with Z-touch® Laser Registration Pointer and Softouch® Pointer. However you enter the O.R., your plan transfers with you—ready to guide the decisions that follow.

RegistrationAutomatic Registration with Loop-X Mobile Imaging Robot 

Intraoperative X-ray images acquired with Loop-X can be seamlessly transferred to Brainlab Navigation, simplifying registration regardless of patient position—including prone cases. Its 121 cm gantry opening and non-isocentric imaging support patient-tailored O.R. setups. During tumor resection, Loop-X may support visualization of cranial structures and may assist in detecting lesions and intraoperative bleeding.

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RegistrationAutomatic Registration with iMRI, iCT and other imaging modalities 

Automatic Registration integrates intraoperatively acquired images with image-guided surgery, adding current imaging data to navigation while maintaining the preoperative plan. AIR iMRI supports automatic registration for various MR scanners, while Universal Automatic Registration enables integration with imaging modalities such as iCT, rotational angiography and cone-beam CT—both without the need to access anatomical landmarks.

Automatic Image Registration (AIR) technology in action

RegistrationManual Registration

We offer contact-free options with Z-touch® Laser Registration Pointer and touch-based options with Softouch® Pointer for manual registration like Surface Matching, avoiding the need for a foot pedal. They enable registration of preoperative CT and MR images.

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Navigate with the full picture

Once you’re in the O.R., your plan needs to remain available throughout the procedure. Our intraoperative neuronavigation tools bring your preoperative roadmap to life—delivering real-time, data-rich navigation that keeps you oriented, informed and focused on the patient at every stage of the resection.

Cranial NavigationEvery decision, informed

During tumor resection, the stakes of every navigational decision are high—and the margin for distraction is zero. Our neuronavigation system brings your preoperative plan, functional mapping data, fiber tracts and real-time imaging together in a single, intuitive view, showing only what's clinically relevant at each moment of the resection. Instrument calibration is automated and touchless without breaking your workflow. As an open platform, Cranial Navigation integrates with Brainlab and third-party instruments, helping the workflow fit the way you operate.

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EM NavigationNavigate without constraints

When a case calls for touchscreen-free, pinless navigation—especially for pediatric patients—electromagnetic tracking adds flexibility to the workflow. Cranial EM Navigation supports workflow-guided setup, registration and navigation across a range of patient positions, including challenging ones. Designed for ease of use, an integrated remote control lets surgeons freeze the screen, capture screenshots or acquire a trajectory without touching the display so they can focus and keep the workflow moving.

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Microscope NavigationBring clarity into view

In tumor resection, the microscope is where the most critical decisions happen—and Microscope Navigation ensures that the data you need is always in your line of sight. AR overlays bring tumor boundaries, fiber tracts and critical anatomical structures directly into your surgical view, helping you navigate the margin between tumor and healthy tissue with confidence. Robotic microscope positioning adjusts automatically so you can stay focused on the resection, not the equipment.

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Ultrasound NavigationSee more in every dimension

During resection, ultrasound adds an intraoperative view of the anatomy to the preoperative plan. Ultrasound Navigation supports 2D and 3D navigation, allowing you to compare live ultrasound with patient data or assess 3D datasets in axial, coronal and sagittal views. Serial 3D acquisitions help track resection progress, while registered instruments support navigation within the current dataset. Together, these capabilities provide intraoperative insights to help you stay oriented as the procedure progresses.

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Stay true as anatomy changes

Even the most precise preoperative plan must account for the challenge of brain shift. As the procedure progresses, changes in anatomy or registration can create discrepancies between preoperative images and the surgical field—sometimes without being immediately apparent. The information guiding you should reflect the anatomy in front of you.

Microscope Navigation UpdateUpdate navigation through visible anatomy

During resection, Microscope Navigation Update allows you to update registration by comparing visible cortical vessels with their corresponding MIP overlays or by matching preplanned objects. Touch-based alignment helps identify and correct small registration discrepancies, so navigation can remain aligned with the patient’s anatomy throughout the procedure. Registration can be updated during resection and repeated when required and feasible, including for previously segmented objects.

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Ultrasound NavigationSee what’s changed

As tumor resection progresses, Ultrasound Navigation brings real-time intraoperative imaging into the navigation workflow, helping you reassess the tumor and surrounding anatomy, monitor resection progress and identify suspected residual tumor. By correlating live ultrasound with preoperative MRI and planning data, it also helps you stay oriented to the preoperative tumor plan as anatomy changes throughout the procedure.

Screenshot of the Ultrasound Navigation: real-time intraoperative imaging for cranial image guidance

Ultrasound Snap to MRIRealign with current anatomy

Ultrasound Snap to MRI3 supports semi-automated rigid fusion of intraoperative cranial ultrasound with preoperative MRI. By updating the registration between the current ultrasound view and the preoperative plan, it helps maintain orientation and supports navigation throughout tumor resection.

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Intraoperative NeuromonitoringKeep function in focus

As resection progresses, Intraoperative Neuromonitoring with AVALANCHE® PLUS3 complements the anatomical picture with live functional information. It provides information about motor and other essential functions throughout the procedure, helps verify the location of functional structures and enables seamless adaptation of mapping and monitoring as the surgical situation evolves. Repeated stimulation settings and acoustic cues support standardized neuromonitoring, with key actions accessible via the touchscreen.

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Experience innovation up close

See our cranial workflow in action. Request a personalized demo to witness how our solutions can support you in precise tumor resection.

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  1. The statements made by the surgeon during this interview represent their personal opinion and experiences. These statements may not be supported by scientific evidence or peer-review research. For verified information about the device, please refer to the manufacturer’s official documentation or consult clinical guidance.

  2. Krieg S. et al., Preoperative motor mapping by navigated transcranial magnetic brain stimulation improves outcome for motor eloquent lesions. Neuro Oncol. first published online February 9, 2014 

  3. Not yet commercially available in several countries. Please contact your sales representative.