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Elements Contrast Clearance Analysis is a novel MRI-based methodology for the high resolution depiction of contrast clearance and accumulation, allowing for the differentiation of brain regions with high and low vascular activity

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TRAMs Clinical Use

Clinical Use

High resolution Contrast Clearance Analysis results derived from conventional 3D contrast-enhanced MRI data provide additional insight into tumor characteristics and thereby support clinicians during analysis of vascular activity. Elements Contrast Clearance Analysis serves clinical specialties including radiation oncology, neurosurgery, neuro-oncology and neuroradiology

  • High resolution differentiation of contrast clearance and accumulation
  • Allows for the identification of brain regions with high and low vascular activity
  • Supports ongoing assessment
TRAMs Methodology


Contrast Clearance Analysis, a novel MRI-based methodology for distinct differentiation of contrast clearance and accumulation, allows for the depiction of brain regions with high (blue) and low (red) vascular activity. The methodology was developed at Sheba Medical Center, Tel Aviv, with technology provided by Brainlab.

  • Two acquisitions of standard 3D T1-weighted MRI—one 5 minutes and another 60-105 minutes after injection of a standard dose of contrast agent
  • First series is intelligently subtracted from the second for Contrast Clearance Analysis
  • The analysis results are high resolution, volumetric maps distinguishing regions of contrast clearance (blue) from contrast accumulation (red) more than one hour post contrast injection